//"Neurochemical issues are usually associated with lack of receptors, or lack of production. Like genetically caused depression."// YES!! there are many types of neurochemical abnormalities, but in both dog-aggressive dogs, and in shy dogs, the numbers of receptors on for serotonin, and dopamine, were off, as well as the genes to determine to the transporters, were all off, as well. Interestingly, when compared with the 'normal' dogs, the shy dogs always had too few receptors, and the dog-aggressive dogs always had too many receptors. ~~~It is TWO DIFFERENT DISORDERS~~~. (i might have that backwards, it might be other way around, about which dog always had too many, and which type of dog always had too few receptors......) i will post that thread of genetic research this week, it shouldn't take me long, i have already posted it on other boards for owners of aggressive dogs, and i'll tag you to know it is there for you to look over.